Introduction During his twenty years of research Professor Karl-Göran Tranberg came to an understanding of how to stimulate the immune system into attacking cancer cells on a systemic level. His method of choice was to gently apply thermal heat to a solid tumor by inserting a laser fiber inside it. The precision and steadiness of the laser created the ability to withhold a temperature of approximately 46 C degrees at the tumor border for circa 30 minutes without damaging healthy surrounding tissue. His method allowed intact tumor antigens to be released and stimulate a tumor specific systemic immune response. At a glance, perhaps it seems like a simple treatment principle but the imILT procedure requires high precision instruments and effective guidance control. When the immune system is triggered by the imILT treatment not only the treated tumor dies but also distant metastases, this abscopal effect is the result of a systemic immune reaction causing the natural born killer cells, T-cells, to seek out and destroy cancerous cells in the body. This immunological process also, in principle, sets a vaccine-like immunological memory which ensures the treated cancer doesn´t return. Tranberg’s early pre-clinical and clinical research (72 patients) has shown great promise and last year CLS presented a poster at the Society of Immunotherapy of Cancer which was titled, “Anti-tumor effects and immunological response following immune stimulating interstitial laser thermotherapy” and described the initial experiences from CLS pre-clinical trials and laid out evidence for the abscopal effect and immunological memory generated by the imILT treatment when tested in mice.
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